| TW | LW | Title | Studio | Wknd Gross | % Change | Theaters | Average | Total Gross | Budget* | Week# |
| 1 | N | The Twilight Saga: New Moon | Sum. | $142,839,137 | -- | 4,024 | $35,497 | $142,839,137 | $50 | 1 |
| 2 | N | The Blind Side | WB | $34,119,372 | -- | 3,110 | $10,971 | $34,119,372 | - | 1 |
| 3 | 1 | 2012 | Sony | $26,410,206 | -59.5% | 3,408 | $7,749 | $108,131,263 | $200 | 2 |
| 4 | N | Planet 51 | Sony | $12,286,129 | -- | 3,035 | $4,048 | $12,286,129 | - | 1 |
| 5 | 2 | A Christmas Carol (2009) | BV | $12,275,024 | -45.0% | 3,578 | $3,431 | $79,836,002 | $200 | 3 |
| 6 | 3 | Precious: Based on the Novel "Push" by Sapphire | LGF | $10,881,772 | +85.2% | 629 | $17,300 | $21,277,521 | $10 | 3 |
| 7 | 4 | The Men Who Stare at Goats | Over. | $2,829,031 | -51.7% | 2,056 | $1,376 | $27,680,089 | $25 | 3 |
| 8 | 7 | Couples Retreat | Uni. | $1,943,075 | -53.3% | 1,712 | $1,135 | $104,992,030 | $70 | 7 |
| 9 | 6 | The Fourth Kind | Uni. | $1,747,085 | -62.1% | 1,648 | $1,060 | $23,359,890 | - | 3 |
| 10 | 5 | Michael Jackson's This Is It | Sony | $1,617,417 | -68.2% | 1,640 | $986 | $70,258,545 | - | 4 |
| 11 | 9 | Law Abiding Citizen | Over. | $1,606,053 | -57.7% | 1,327 | $1,210 | $70,018,193 | $50 | 6 |
| 12 | 11 | Pirate Radio | Focus | $1,460,592 | -49.7% | 883 | $1,654 | $5,184,068 | $50 | 2 |
| 13 | 8 | Paranormal Activity | Par. | $1,401,112 | -65.3% | 1,902 | $737 | $106,082,922 | $0.02 | 9 |
| 14 | N | An Education | SPC | $826,755 | +24.9% | 303 | $2,729 | $4,268,905 | - | -32768 |
| 15 | 12 | Where the Wild Things Are | WB | $688,060 | -71.5% | 1,010 | $681 | $74,665,359 | $100 | 6 |
| 16 | 14 | The Boondock Saints II: All Saints Day | App. | $599,257 | -42.0% | 204 | $2,938 | $3,552,730 | $8 | 4 |
| 17 | 10 | The Box | WB | $494,345 | -84.3% | 965 | $512 | $14,503,106 | $30 | 3 |
| 18 | 18 | A Serious Man | Focus | $444,008 | -32.4% | 198 | $2,242 | $7,476,004 | - | 8 |
| 19 | 13 | Astro Boy | Sum. | $406,074 | -76.2% | 724 | $561 | $18,621,561 | $65 | 5 |
| 20 | N | Kurbaan | UTV | $403,678 | -- | 83 | $4,864 | $403,678 | - | 1 |
| 21 | 15 | Amelia | FoxS | $248,012 | -73.2% | 384 | $646 | $13,766,323 | $40 | 5 |
| 22 | N | Bad Lieutenant: Port of Call New Orleans | First | $245,398 | -- | 27 | $9,089 | $245,398 | - | 1 |
| 23 | 21 | Coco Before Chanel | SPC | $236,495 | -44.2% | 184 | $1,285 | $5,288,153 | - | 9 |
| 24 | 24 | The Fantastic Mr. Fox | Fox | $203,512 | -23.5% | 4 | $50,878 | $562,048 | - | 2 |
| 25 | 22 | Cloudy with a Chance of Meatballs | Sony | $172,031 | -52.4% | 231 | $745 | $122,308,668 | $100 | 10 |
| 26 | 42 | Julie & Julia | Sony | $149,746 | +170.9% | 268 | $559 | $93,900,336 | $40 | 16 |
| 27 | 19 | Zombieland | Sony | $116,260 | -75.5% | 149 | $780 | $74,803,711 | $23.6 | 8 |
| 28 | 46 | The Messenger | Osci. | $110,112 | +147.3% | 31 | $3,552 | $167,346 | - | 2 |
| 29 | 25 | G-Force | BV | $108,735 | -23.1% | 165 | $659 | $119,251,463 | $150 | 18 |
| 30 | N | Broken Embraces | SPC | $107,111 | -- | 2 | $53,556 | $107,111 | - | 1 |
| 31 | 16 | The Stepfather (2009) | SGem | $101,187 | -87.9% | 191 | $530 | $29,062,561 | $20 | 6 |
| 32 | 35 | The Invention of Lying | WB | $96,217 | +25.1% | 181 | $532 | $18,219,219 | $18.5 | 8 |
| 33 | 20 | Saw VI | LGF | $91,875 | -79.6% | 178 | $516 | $27,669,413 | $11 | 5 |
| 34 | 26 | Inglourious Basterds | Wein. | $78,017 | -41.4% | 163 | $479 | $120,278,316 | $70 | 14 |
| 35 | 23 | Cirque du Freak: The Vampire's Assistant | Uni. | $74,920 | -73.6% | 140 | $535 | $13,838,130 | $40 | 5 |
| 36 | 33 | Under the Sea 3D | WB | $71,994 | -2.9% | 30 | $2,400 | $18,760,505 | - | 41 |
| 37 | 27 | The Informant! | WB | $62,409 | -51.4% | 131 | $476 | $33,213,811 | $22 | 10 |
| 38 | 32 | The Hangover | WB | $56,972 | -29.0% | 103 | $553 | $277,156,483 | $35 | 25 |
| 39 | 29 | Shorts | WB | $54,458 | -39.7% | 131 | $416 | $20,797,067 | - | 14 |
| 40 | 30 | New York, I Love You | Viv. | $46,770 | -46.2% | 37 | $1,264 | $1,466,395 | - | 6 |
| 41 | 31 | All About Steve | Fox | $44,290 | -48.2% | 93 | $476 | $33,806,061 | - | 12 |
| 42 | 36 | 9 | Focus | $43,390 | -38.4% | 92 | $472 | $31,691,649 | $30 | 11 |
| 43 | 37 | Whip It | FoxS | $41,821 | -39.1% | 83 | $504 | $12,994,912 | $15 | 8 |
| 44 | 44 | The Maid | Elep. | $37,859 | -22.2% | 14 | $2,704 | $323,487 | - | 6 |
| 45 | 39 | Harry Potter and the Half-Blood Prince | WB | $35,134 | -43.2% | 72 | $488 | $301,865,854 | $250 | 19 |
| 46 | 48 | Space Station 3-D (IMAX) | Imax | $34,922 | -10.6% | 6 | $5,820 | $80,245,679 | - | 397 |
| 47 | 34 | Capitalism: A Love Story | Over. | $33,675 | -57.5% | 52 | $648 | $14,266,331 | - | 9 |
| 48 | 28 | Good Hair | RAtt. | $33,289 | -64.3% | 38 | $876 | $4,061,847 | - | 7 |
| 49 | 45 | Ice Age: Dawn of the Dinosaurs | Fox | $31,149 | -34.1% | 59 | $528 | $196,573,705 | $90 | 21 |
| 50 | 38 | The Time Traveler's Wife | WB (NL) | $31,105 | -53.6% | 82 | $379 | $63,387,284 | $39 | 15 |
| 51 | 53 | La Danse: Le Ballet de L'Opera de Paris | Zipp. | $31,032 | +10.4% | 7 | $4,433 | $113,124 | - | 3 |
| 52 | 43 | Bright Star | App. | $26,476 | -47.3% | 35 | $756 | $4,390,226 | $8.5 | 10 |
| 53 | 56 | Antichrist | IFC | $26,325 | +2.1% | 14 | $1,880 | $326,651 | - | 5 |
| 54 | 40 | Halloween II (2009) | W/Dim. | $25,969 | -57.7% | 66 | $393 | $33,386,128 | $15 | 13 |
| 55 | 41 | Surrogates | BV | $22,348 | -59.8% | 48 | $466 | $38,408,343 | $80 | 9 |
| 56 | 52 | Paris | IFC | $20,736 | -30.2% | 21 | $987 | $892,904 | - | 10 |
| 57 | 50 | (Untitled) | Gold. | $19,521 | -42.2% | 11 | $1,775 | $201,342 | - | 5 |
| 58 | 51 | The September Issue | RAtt. | $18,336 | -43.2% | 13 | $1,410 | $3,765,677 | - | 13 |
| 59 | 49 | The Final Destination | WB (NL) | $17,936 | -48.5% | 43 | $417 | $66,466,372 | $40 | 13 |
| 60 | 57 | Magnificent Desolation (IMAX) | Imax | $16,685 | -28.4% | 3 | $5,562 | $30,362,092 | - | 218 |
| 61 | 64 | Sea Monsters: A Prehistoric Adventure (IMAX) | NGC | $16,589 | +25.4% | 8 | $2,074 | $22,530,595 | - | 112 |
| 62 | 58 | More Than a Game | LGF | $14,949 | -30.1% | 46 | $325 | $944,527 | - | 8 |
| 63 | N | Red Cliff | Magn. | $13,104 | -- | 2 | $6,552 | $14,873 | - | 1 |
| 64 | 65 | Aliens in the Attic | Fox | $12,247 | -7.3% | 23 | $532 | $25,200,412 | $45 | 17 |
| 65 | N | The Sun | Lorb. | $11,588 | -- | 1 | $11,588 | $15,122 | - | 1 |
| 66 | 54 | The Damned United | SPC | $10,966 | -60.7% | 16 | $685 | $385,049 | - | 7 |
| 67 | 60 | (500) Days of Summer | FoxS | $10,694 | -35.3% | 20 | $535 | $32,391,374 | $7.5 | 19 |
| 68 | 71 | The Yes Men Fix the World | Shad. | $10,326 | -13.6% | 12 | $861 | $131,029 | - | 9 |
| 69 | 90 | That Evening Sun | Free | $10,278 | +175.5% | 4 | $2,570 | $25,288 | - | 3 |
| 70 | 59 | Yoo-Hoo, Mrs. Goldberg | ICir | $7,997 | -54.7% | 10 | $800 | $1,116,839 | - | 20 |
| 71 | 86 | Amreeka | NGC | $6,400 | +29.9% | 7 | $914 | $600,826 | - | 12 |
| 72 | 61 | It Might Get Loud | SPC | $6,394 | -59.6% | 11 | $581 | $1,585,591 | - | 15 |
| 73 | 55 | Gentlemen Broncos | FoxS | $6,146 | -77.7% | 9 | $683 | $105,431 | $10 | 4 |
| 74 | N | Fix | Mang. | $5,951 | -- | 1 | $5,951 | $5,951 | - | 1 |
| 75 | 62 | The Secrets of Jonathan Sperry | 5&2 | $5,563 | -64.7% | 8 | $695 | $1,142,963 | - | 10 |
| 76 | 67 | Uncertainty | IFC | $5,272 | -59.7% | 1 | $5,272 | $21,560 | - | 2 |
| 77 | N | Defamation | FRun | $4,725 | -- | 4 | $1,181 | $4,725 | - | 1 |
| 78 | 92 | Bronson | Magn. | $4,707 | +30.6% | 4 | $1,177 | $90,857 | - | 7 |
| 79 | 81 | Jennifer's Body | Fox | $4,667 | -45.6% | 10 | $467 | $16,204,793 | $16 | 10 |
| 80 | N | Mammoth | IFC | $4,531 | -- | 1 | $4,531 | $4,531 | - | 1 |
| 81 | 107 | The Way We Get By | ICir | $4,520 | +292.7% | 4 | $1,130 | $99,141 | - | 19 |
| 82 | 72 | Four Seasons Lodge | FRun | $4,486 | -61.5% | 1 | $4,486 | $26,032 | - | 2 |
| 83 | 89 | Ong Bak 2: The Beginning | Magn. | $4,001 | -10.0% | 6 | $667 | $82,131 | - | 5 |
| 84 | 73 | The House of the Devil | Magn. | $3,927 | -64.6% | 3 | $1,309 | $72,238 | - | 4 |
| 85 | 69 | Fame (2009) | MGM | $3,830 | -69.9% | 23 | $167 | $22,371,648 | $18 | 9 |
| 86 | 84 | 35 Shots of Rum | CGld | $3,814 | -31.8% | 3 | $1,271 | $99,749 | - | 10 |
| 87 | 94 | A Woman in Berlin | Strand | $3,156 | -4.5% | 4 | $789 | $291,812 | - | 19 |
| 88 | 117 | The Baader Meinhof Complex | Vita. | $2,841 | +392.4% | 2 | $1,421 | $468,768 | - | 14 |
| 89 | 83 | Horse Boy | Zeit. | $2,820 | -53.9% | 2 | $1,410 | $119,474 | - | 8 |
| 90 | N | The Missing Person | Strand | $2,715 | -- | 1 | $2,715 | $2,715 | - | 1 |
| 91 | 88 | Seraphine | MBox | $2,638 | -44.7% | 4 | $660 | $848,955 | - | 25 |
| 92 | 95 | Youssou N'Dour: I Bring What I Love | Shad. | $2,450 | -25.8% | 3 | $817 | $163,523 | - | 24 |
| 93 | 79 | Crude | FRun | $2,198 | -74.6% | 2 | $1,099 | $152,578 | - | 11 |
| 94 | 80 | Collapse | Vita. | $2,159 | -74.9% | 2 | $1,080 | $26,088 | - | 3 |
| 95 | 63 | Play the Game | Slow | $2,060 | -86.2% | 8 | $258 | $659,483 | - | 39 |
| 96 | 66 | Dare | Imag. | $2,056 | -84.4% | 1 | $2,056 | $18,088 | - | 2 |
| 97 | 108 | Food, Inc. | Magn. | $1,892 | +68.6% | 5 | $378 | $4,417,124 | - | 24 |
| 98 | 85 | Departures | Reg. | $1,870 | -64.9% | 3 | $623 | $1,487,901 | - | 26 |
| 99 | 87 | Passport to Love | Vari. | $1,832 | -62.3% | 2 | $916 | $172,453 | - | 7 |
| 100 | 110 | Big Fan | FInd. | $1,527 | +55.8% | 3 | $509 | $225,071 | - | 13 |
| 101 | 91 | Mystery Team | RAtt. | $1,476 | -59.8% | 1 | $1,476 | $27,487 | - | 13 |
| 102 | 105 | Lorna's Silence | SPC | $1,403 | +2.7% | 2 | $702 | $337,082 | - | 17 |
| 103 | 119 | Trucker | Mont. | $1,247 | +186.7% | 3 | $416 | $46,687 | - | 7 |
| 104 | 112 | The Cove | RAtt. | $1,215 | +49.8% | 6 | $203 | $844,816 | - | 17 |
| 105 | 97 | White on Rice | Vari. | $1,141 | -54.2% | 2 | $571 | $63,280 | - | 11 |
| 106 | 103 | World's Greatest Dad | Magn. | $1,038 | -30.4% | 2 | $519 | $221,210 | - | 14 |
| 107 | 116 | The Burning Plain | Magn. | $1,001 | +41.6% | 2 | $501 | $200,399 | - | 10 |
| 108 | 99 | Killing Kasztner | SkyI | $978 | -57.4% | 1 | $978 | $27,187 | - | 5 |
| 109 | 68 | Women in Trouble | Scre. | $966 | -92.4% | 1 | $966 | $18,097 | - | 2 |
| 110 | - | Mississippi Mermaid (re-issue) | FDesk | $873 | -- | 1 | $873 | $12,210 | - | 15 |
| 111 | 123 | Under Our Skin | Shad. | $684 | +242.0% | 1 | $684 | $92,022 | - | 23 |
| 112 | 100 | Endgame | Mont. | $450 | -77.1% | 2 | $225 | $5,922 | - | 3 |
| 113 | 82 | Oh My God? | Mitro. | $384 | -95.4% | 1 | $384 | $12,117 | - | 2 |
| 114 | 114 | Humble Pie | Mont. | $305 | -59.8% | 1 | $305 | $2,931 | - | 3 |
| 115 | 104 | The Beaches of Agnes | CGld | $301 | -79.8% | 2 | $151 | $213,159 | - | 21 |
| 116 | 118 | The Legend of God's Gun | Indic. | $202 | -58.5% | 1 | $202 | $243,768 | - | 71 |
| 117 | 122 | Fallen Idol: The Yuri Gagarin Conspiracy | Indic. | $189 | -6.4% | 1 | $189 | $10,583 | - | 8 |
| 118 | - | The Stoning of Soraya M. | RAtt. | $93 | -- | 1 | $93 | $637,197 | - | 22 |